Introduction. Lymphangitis carcinomatosa describes a condition of diffuse infiltration of the lymphatics of both the lungs by malignant cells. Pulmonary lymphangitic carcinomatosis (PLC) is a metastatic lung disease characterised by the diffuse infiltration and obstruction of the pulmonary parenchymal. The malignant pulmonary embolization syndromes, pulmonary tumor emboli and lymphangitic carcinomatosis, are associated with a poor.

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Further study of nebulization chemotherapy, a new chemotherapeutic method in the treatment of lung carcinomas: National Center for Biotechnology InformationU. Distribution of changes is variable, but most are asymmetric and patchy 3. It may also occur by retrograde spread into the lymphatics from the mediastinal and hilar lymph nodes. Please review our privacy policy.

J R Coll Surg Edinb. Radiological appearances of lymphangitis carcinomatsa of the lung. Nebulization chemotherapy for lymphangitis carcinomatosa.

Clinical presentation is variable. A computerized tomography CT carcinomtosa of the abdomen and pelvis revealed thickening of the distal stomach with peri-gastric nodes. Prognosis of patients with lymphangitic carcinomatosis is poor, with approximately half of patients succumbing to their illness within a year of diagnosis 2,3.

On chest radiography abnormalities are found to be slightly more common in the right lung than in the left. Arterial blood gas analysis was suggestive of Type I respiratory failure. It is usually bilateral but may be unilateral, especially in cases of lung and breast cancer. Lymphangitiis patients experience dyspnoea and abnormal pulmonary function tests early in the course of the disease, well before any carcunomatosa abnormalities are evident, whereas others remain asymptomatic until much later 4.


J R Soc Med. Lymphangitic spread of metastatic cancer to the lung. Lymphangitis carcinomatosa is inflammation of the lymph vessels lymphangitis caused by a malignancy. She was scheduled for an endoscopic evaluation, but she presented to the emergency on the second day with acute breathlessness. Pulmonary lymphangitic carcinomatosis from occult stomach carcinoma lympbangitis young adults: In most cases, lymphangitis carcinomatosis is caused by the dissemination of a tumor with its cells along the lymphatics.

Ramakrishnan Ayloor Seshadri, Phone: In the lung, this is often caused by a centrally located mass, near the hilum of the lung lymphanvitis blocks lymphatic drainage. Received Feb 9; Accepted Jan Involvement may be diffusely of both, or predominantly of one compartment or the other 4.

Lymphangitis Carcinomatosa: Report of a Case and Review of Literature

Unfortunately up to a quarter of patients with subsequently established lymphangitic carcinomatosis have normal chest x-rays 2. As such a ‘stable’ appearance when compared to previous imaging does not necessarily exclude the diagnosis. Open in a separate window. How to cite this URL: Check for errors and try again.

A helpful mnemonic for lymphangitic carcinomatosis is sometimes used for its common causes. Computed tomography and magnetic resonance of the thorax.

Views Read Edit View history. Lymphangitis carcinomatosa is a rare clinico-pathological entity. Breast, lung, stomach, pancreas, and prostate cancers are the most common tumors that result in lymphangitis. The diagnosis rests on a high index of suspicion in the setting of progressive respiratory failure. Case 6 Case 6. Lymphangitis carcinomatosa may precede or obscure or dominate any local symptoms and present as a diagnostic problem in dyspnoea.


Lymphangitis carcinomatosa may show the presence of Kerley B lines on chest X-ray. As she was not responding to antibacterial therapy, empirical antifungal and anti viral drugs were added.

J R Soc Med ; Unable to process the form. Lymphangitis carcinomatosa is a term introduced by Troisier in to describe diffuse infiltration of the lymphatics of both the lungs by malignant cells. However steroid administration may produce symptomatic improvement mainly by alleviating breathlessness [ 1 ]. Radiographic appearances can most easily be divided into those due to the involvement of the peripheral interlobular septa and central lymphatic system.

Lymphangitis carcinomatosis of the lungs.

Lymphangitis Carcinomatosa: Report of a Case and Review of Literature

We also review the relevant literature pertaining to this rare entity. Respiratory system examination was normal.

Br J Cancer ; Chest radiographs revealed diffuse haziness in both lower lung fields but there was no evidence of pleural effusion or pulmonary metastatic nodules. It may be the only manifestation of an occult malignancy and should be included in the differential diagnosis of dyspnoea, especially in young patients in whom this diagnosis is usually not suspected. Treatment is determined by the histology of the primary tumor, but in general, relies on systemic chemotherapy.

Lymphangitis carcinomatosa describes a condition of diffuse infiltration of the lymphatics of both the lungs by malignant cells.