Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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Involvement of folliculo-sebaceous unit. Some of the early lesions have demonstrated lymphocytes within follicular walls [ 29 ]. July 05, Citation: Report of a new case and brief literature review.

The majority of granulomas were perifollicular in location and were comprised of histiocytes, lymphocytes, and multinucleated giant cells.

A Review of Lupus Miliaris Disseminatus Faciei-Like Histopathologic Changes in 10 Cases

One case demonstrated a perifollicular lymphocytic infiltrate with minimal follicular invasion. Sign in to access your subscriptions Sign in to your personal account. A year-old faciej presented with 4 months history of asymptomatic, reddish-raised lesions over the face, earlobes, and the neck.

No other body areas were affected. Formalin-fixed, paraffin-embedded specimens were examined by hematoxylin-eosin staining.

Lupus miliaris disseminatus faciei

Hymes, MD ; Leonard H. Histologic features of 10 cases of lupus miliaris disseminatus faciei. Histologic spectrum of LMDF. Get free access to newly published articles Create a personal account or sign in to: Diascopy may reveal apple-jelly nodules [ 1 – 3 ].


One patient presented with a solitary lesion of the lower back with no facial involvement dissemnatus another presented with a solitary lesion of the antihelix without facial involvement.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Lupus miliaris disseminatus faciei.

Epithelioid granulomas have been experimentally produced by intradermal injection of sebum and comedones [ 19 ]. How to cite this URL: Sarcoidosis is considered to be a cell mediated granulomatous disease.

The fully developed lesions are subclassified into four groups: Register for email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts.

Dermatology Online J ; Fully developed lesions typically demonstrate perifollicular epithelioid miliaeis, sometimes with follicular rupture.


Scarring of lupus miliaris disseminatus faciei: El Darouti M, Zaher H. Studies revealing intense lysozyme reaction in LMDF miliarie that an infectious agent may induce cell-mediated immunity, with subsequent formation of epithelioid cell granulomas [ 12 ]. Significant clinical improvements in skin lesions were noted 4 weeks after the first treatment.


This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and luphs work is not changed in any way.

Lupus miliaris disseminatus faciei: It is considered by some to be part of a spectrum between granulomatous rosacea and sarcoidosis [ 6 ].

Journal List An Bras Dermatol v. While this finding could represent a non-immunological foreign body granuloma reaction, the presence of moderate to intense staining of lysozyme in the epithelioid histiocytes and multinucleate giant cells of LMDF suggests a role for cell-mediated immunity. Also, the lesions respond to treatments that are often used for acne vulgaris and rosacea and may result in ice-pick scarring that is indistinguishable from that seen in acne vulgaris.

Red papules on the face with secondary scarring. Guidelines Disseeminatus Special Issues. Disxeminatus Online J ;