Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

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The disease prevalence has not been clearly specified so far but this is not a condition commonly found in routine clinical practice.

However, no ‘gold standard’ therapy exists among these treatment modalities.

Tazarotene Is an Effective Therapy for Elastosis Perforans Serpiginosa

The first description of EPS was most likely published in Fisherand at that time, because of the clinical presentation, this condition was classified into a group of diseases with hyperkeratosis. Views Read Edit View history. EPS is more commonly reported in men and usually occurs during childhood or early adulthood 1. Treatment with topical tretinoin including topical 0.

Expression of the kDa elastin receptor in perforating skin disorders. The patient’s medical and family history was also negative for EPS or any other connective tissue diseases.

Penicillamine-induced elastosis of the mucosal lip. Conflict of interest The authors declare no conflict of interest. See the DermNet NZ bookstore. Copyright American Medical Association. Find articles by Si-Hyung Lee. Purchase access Subscribe now. This article has been cited by. Despite treatment with topical 0. Sign in to customize your interests Sign in to your personal account. Topical imiquimod and topical tazarotene therapy serpiginossa reported to improve EPS skin lesions 15 Elastosis perforans serpiginosa is a rare skin disease characterized by transepidermal elimination of abnormal elastic fibers.


Elastosis perforans serpiginosa on the background with acanthosis nigricans. Adjacent inflammation with dermal necrosis, both within and surrounding the epithelia, was evident. Create a free personal account to access your subscriptions, sign up for alerts, and more.

Table 1 Diseases associated with elastosis perforans serpiginosa. All five Korean patients including our patient presented with skin lesions on the neck, the most frequently affected Eprforans site. Indian J Dermatol ; In addition to a marked increase in the amount and thickness of serpiginnosa dermal elastic tissue, a chronic inflammatory infiltrate containing lymphocytes, macrophages, or multinucleated giant cells may be present in the dermis pedforans the sites of perforation.

We report an additional case of this rare serpiginoss condition and review EPS cases described in the Korean literature. These lesions were associated with a 6-cm-long scar on the posterolateral aspect of the left side of the neck.

Elastosis perforans serpiginosa | DermNet NZ

J Am Acad Dermatol. The skin at the entrance of the tunnel accumulates chronic inflammatory infiltrate composed often of giant cells [ 1112 ]. Disorders of eerpiginosa tissue.

In the second patient they observed a slight reduction in lesions after simultaneous treatment with 0. She had a history of cystinuria, which had been treated with D-penicillamine for several years, but the D-penicillamine therapy had been discontinued 2 years before the onset of the eruption.

Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson’s disease with penicillamine. Open in a separate window. Elastosis perforans serpiginosa EPS is a rare skin disorder in which abnormal elastic tissue fibre passes from the serpifinosa dermis inner layer of skin to the epidermis outer layer of skin.

Related articles D-penicillamine elastosis perforans serpiginosa lumpy-bumpy elastic fibers. Exfoliating erythematous papular lesions with a diameter of a few millimeters within the skin of the left cheek and upper and lower limbs were observed. The pinhole method using a carbon dioxide laser showed complete clearing without post-treatment scarring Table 1 A summary of the 5 cases of elastosis perforance serpiginosa reported in the Korean literature including our case.


Tazarotene is an effective therapy for elastosis perforans serpiginosa. Sign in to save your search Sign in to your personal account. Kyrle disease Reactive perforating collagenosis Elastosis perforans serpiginosa Perforating folliculitis Acquired perforating dermatosis. Infobox medical condition new All stub articles.

Elastosis perforans serpiginosa, Therapeutics. There have not been published any reports about EPS and Koebner phenomenon so far.

Brown papules coalescing to form serpiginous plaques with central clearing, atrophy and raised hyperkeratotic rim over sides of the neck Click here to view.

Elastosis perforans serpiginosa – Wikipedia

A year-old man presented to Gangnam Severance Hospital with serpigknosa 2-year history of skin eruptions on his neck, which were refractory to topical antifungal or steroid treatment. This study was presented as a poster at the annual meeting of the American Academy of Dermatology, San Francisco, Calif, March One mechanism of action of tazarotene in psoriasis is thought to be attributable to the down-regulation of keratins 6, 10, and Abnormalities of dermal fibrous and elastic tissue Cutaneous condition stubs.

Published online Feb Published by Wolters Kluwer – Medknow. A summary of the 5 cases of elastosis perforance serpiginosa reported in the Korean literature including our case. Laser treatment, including carbon dioxide laser and Er: Psoriasis and Down syndrome: